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目的探讨高危早期子宫内膜癌术后辅助放疗与化疗的临床效果。方法选取2011年11月至2013年11月间新疆维吾尔自治区人民医院收治的接受手术治疗的90例高危早期子宫内膜癌患者,采用随机数表法分为放疗组与化疗组,每组45例,比较两组患者的近期不良反应及随访3年的生存率、局部复发率和远处转移率。结果与放疗组比较,化疗组骨髓抑制、肠道反应、泌尿系统反应及皮肤反应发生率均较低,差异均有统计学意义(均P<0.05)。放疗组患者的3年生存率、局部复发率和远处转移率分别为66.7%、20.0%和28.9%,化疗组生存率、局部复发率和远处转移率分别为86.7%、8.9%和13.3%,化疗组随访3年生存率较高,局部复发率及远处转移率较低,差异均有统计学意义(均P<0.05)。结论对接受手术治疗的高危早期子宫内膜癌患者术后给予化疗的效果明显优于放疗,局部复发率及远处转移率较低,生存率较高,不良反应较轻。
Objective To investigate the clinical effect of adjuvant radiotherapy and chemotherapy after high-risk early endometrial cancer. Methods From November 2011 to November 2013, 90 cases of high-risk early endometrial carcinoma underwent surgery in People’s Hospital of Xinjiang Uygur Autonomous Region. The patients were divided into radiotherapy group and chemotherapy group by random number table, and 45 cases in each group , The recent adverse reactions and the 3-year survival, local recurrence and distant metastasis were compared between the two groups. Results Compared with radiotherapy group, the incidence of bone marrow suppression, intestinal reaction, urinary system reaction and skin reaction were lower in chemotherapy group (all P <0.05). The 3-year survival rate, local recurrence rate and distant metastasis rate of patients in radiotherapy group were 66.7%, 20.0% and 28.9%, respectively. The survival rate, local recurrence rate and distant metastasis rate were 86.7%, 8.9% and 13.3 %. The 3-year survival rates of the chemotherapy group were higher, the local recurrence rate and distant metastasis rate were lower, the differences were statistically significant (all P <0.05). Conclusions The high-risk early endometrial cancer patients undergoing surgery are better than radiotherapy for postoperative chemotherapy. The local recurrence rate and distant metastasis rate are lower, the survival rate is higher, and the adverse reactions are mild.