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目的:探讨survivin基因启动子-31G/C多态性与中国人群肿瘤易感性的关系。方法:在Pubmed、Medline和中国期刊网全文数据库等数据库中检索相关中外文文献,制定文献纳入及排除标准,运用stata11.0软件进行Meta分析,计算合并的比值比(OR)及95%可信区间(CI)。结果:在中国人群中,survivin基因启动子-31G/C位点携带C碱基的肿瘤易感性是携带G碱基的1.30倍(OR=1.30,95%CI:1.08~1.56),且携带C/C基因型比携带其他基因型更容易导致肿瘤的发生。结论:survivin基因启动子-31G/C位点可能是中国人群肿瘤的一个重要分子标记物。
Objective: To investigate the relationship between survivin gene promoter-31G / C polymorphism and tumor susceptibility in Chinese population. Methods: The relevant Chinese and foreign literatures were retrieved from databases such as Pubmed, Medline and Chinese Journal Net Full-text Database, and the standards of inclusion and exclusion were established. Meta-analysis was performed using stata11.0 software to calculate the combined odds ratio (OR) and 95% confidence Interval (CI). Results: In the Chinese population, the tumor susceptibility to C base at -31G / C locus of survivin promoter was 1.30 times of that of G base (OR = 1.30, 95% CI: 1.08-1.56) / C genotypes are more likely to cause tumors than other genotypes. Conclusion: The -31G / C locus of survivin gene may be an important molecular marker of tumor in Chinese population.