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急性早幼粒细胞白血病(APL)特征性染色体改变形成了t(15;17),涉及PML-RARα融合基因。由于全反式维甲酸、砷剂的使用,目前APL患者的生存期大大延长,但是缓解期的患者仍存在复发的危险性。我们利用实时定量RT-PCR方法检测了56例APL患者PML-RARα融合基因转录本的表达,以便动态观察这些患者的治疗效果,提高治愈率。现将结果报告如下。
A characteristic chromosomal alteration in acute promyelocytic leukemia (APL) forms t (15; 17), involving the PML-RARα fusion gene. Due to the use of all-trans retinoic acid and arsenic, the survival of patients with APL is greatly prolonged at present, but there is still a risk of relapse in patients with remission. We detected the expression of PML-RARα fusion gene transcripts in 56 patients with APL by real-time quantitative RT-PCR in order to dynamically observe the therapeutic effect of these patients and improve the cure rate. The results reported below.