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目的:探究血清氟水平对尿道下裂的易感性。方法:采集贵州籍单纯性尿道下裂患儿和正常健康男性儿童血清样本各21例,采用离子选择电极法测定血清中氟离子浓度,分光光度法测定血清丙二醛(MDA)、一氧化氮(NO)浓度及总抗氧化能力(TAOC);观察两组儿童、不同亚型尿道下裂患儿血清氟离子浓度、MDA、NO浓度及TAOC的改变。结果:尿道下裂组患儿血清氟浓度、MDA及NO水平高于正常对照组儿童,TAOC低于正常对照组(P<0.05);尿道下裂各亚型患儿的血清氟、MDA及NO水平和TAOC比较,差异无统计学意义(P>0.05)。结论:血清氟水平与尿道下裂的发生有关,血清氧化应激水平增加和抗氧化能力的减弱可能是其发病机制之一。
Objective: To investigate the susceptibility of hypospadias to serum fluoride levels. Methods: Twenty-one serum samples from children with simple hypospadias and normal healthy male children from Guizhou Province were collected. The concentrations of fluoride ion in serum were measured by ion-selective electrode method. The levels of serum malondialdehyde (MDA), nitric oxide (NO) and total antioxidative capacity (TAOC). Changes of serum fluoride, MDA, NO and TAOC in children with subtypes of hypospadias were observed. Results: The levels of serum fluoride, MDA and NO in children with hypospadias were higher than those in normal control group, and TAOC was lower than that in normal control group (P <0.05). The levels of serum fluoride, MDA and NO in children with hypospadias There was no significant difference between TAOC and TAOC (P> 0.05). Conclusion: The serum fluoride level is related to the occurrence of hypospadias. The increase of serum oxidative stress level and the decrease of antioxidant capacity may be one of its pathogenesis.