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用ＡＢＣ免疫组化方法观察８５例子宫内膜良恶性病变ｂｃｌ－２和ｐ５３蛋白的表达．结果：各型子官内膜增生ｂｃ１－２高表达，ｐ５３阴性表达。子宫内膜典型腺癌Ⅰ级、Ⅱ级和Ⅲ级ｂｃ１－２阳性分别为１６／２０例，５／８例和２／７例，显示ｂｃ１－２表达随典型腺癌分化程度降低而降低（Ｐ＜０．０５），ｐ５３阳性分别为３／２０Ｒ例，３／８例和４／７例，显示ｐ５３蛋白表达随典型腺癌分化程度降低而升高（Ｐ＜０．０５）子宫内膜癌ｂｃｌ－２和ｐ５３蛋白表达呈负相关。结果还提示，ｂｃ１－２和ｐ５３可能对宫内膜癌具有重要作用。
Immunohistochemical ABC method was used to observe the expression of bcl-2 and p53 in 85 cases of benign and malignant endometrial lesions. Results: There was high expression of bc1-2 in neointimal hyperplasia and negative expression of p53. The positive rates of grade Ⅰ, Ⅱ and Ⅲ bc1-2 in endometrial adenocarcinoma were 16/20, 5/8 and 2/7 respectively, which showed that the expression of bcl-2 was decreased with the differentiation degree of typical adenocarcinoma ( P <0.05). The positive rates of p53 were 3/20 R, 3/8 and 4/7, respectively. The results showed that the expression of p53 protein increased with the differentiation of typical adenocarcinoma (P <0.05) Cancer bcl-2 and p53 protein expression was negatively correlated. The results also suggest that bc1-2 and p53 may play an important role in endometrial cancer.