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目的:评估马栗种子提取物(威利坦)对下肢深静脉血栓后遗症(PTS)的疗效。方法:下肢深静脉血栓后遗症患者65例,口服威利坦10,20,30,60d分别观察患肢周径测定、疼痛、治疗前后慢性静脉功能不全症状严重度评分标准得分(VCSS)等改善情况,采用SPSS10.0统计软件分别进行配对t检验。结果:服用马栗种子提取物后,患肢周径测定、疼痛、治疗前后慢性静脉功能不全症状严重度评分(VCSS)等各项评分均下降,尤其以用药30,60d后更为明显。结论:马栗种子提取物治疗下肢深静脉血栓后遗症疗效显著、安全,患者依从性好,可作为改善静脉功能的首选药物之一。
OBJECTIVE: To evaluate the efficacy of horse chestnut seed extract (Willistan) on the sequelae of deep vein thrombosis (PTS) in the lower extremities. Methods: Sixty-five patients with sequelae of deep vein thrombosis of lower extremities were treated with Oral Willy Tan for 10, 20, 30, and 60 days to observe the changes in peripheral diameter, pain, and severity of chronic venous insufficiency symptom score (VCSS) before and after treatment. The paired t test was performed using the SPSS10.0 statistical software. RESULTS: After taking horse chestnut seed extract, all the scores such as peripheral diameter measurement, pain, and chronic venous insufficiency symptom score (VCSS) before and after treatment decreased, especially after 30 days and 60 days. Conclusion: Horse chestnut seed extract is effective and safe in the treatment of sequelae of deep venous thrombosis of lower extremities. The patient has good compliance and can be used as one of the first choice drugs to improve vein function.