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胞二磷胆碱为脑代谢激活剂,能增强上行性网状结构激活系统的功能,可降低大脑血管阻力,增加大脑血流量,改善大脑血液循环,促进大脑物质代谢。本文综述它的药理作用(包括体内分布、代谢和毒性等)及临床应用(治疗颅脑外伤引起的意识障碍,改善脑卒中亚急性期的上、下肢运动功能和脑卒中后遗症一侧或二侧偏瘫,亦可用于帕金森氏综合征、矽肺、内耳障害,用NLA麻醉的高龄病人木后异常动作)。
Citicoline is a brain metabolic activator, which can enhance the function of the ascending reticular activation system, reduce cerebral vascular resistance, increase cerebral blood flow, improve cerebral blood circulation, and promote cerebral metabolism. This article reviews its pharmacological effects (including in vivo distribution, metabolism and toxicity, etc.) and its clinical application (for the treatment of disturbance of consciousness caused by traumatic brain injury and improvement of motor function of upper and lower limbs in the subacute stage of stroke and one or two sides of stroke sequelae Hemiplegia, also can be used for Parkinson’s syndrome, silicosis, inner ear disorders, anesthesia with NLA elderly patients with abnormal wood movements).