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目的 了解河南省15岁及以上人群精神分裂症患病率、流行情况及影响因素.方法 于2015年在河南省20个区县开展精神障碍流行病学调查,采用多阶段分层随机抽样方法,利用修订后的一般健康问卷(General Health Questionnaire,GHQ-12)作为初步筛查工具,将调查对象按照评分分为高危、中危、低危3组,然后由精神科主治医师采用DSM-Ⅳ轴Ⅰ诊断定式临床访谈诊断量表(SCID)初步对被调查人员进行诊断,采用卡方检验对定性资料进行比较,采用Logistic回归分析对精神分裂症患病影响因素进行分析.结果 完成本次调查共23 846名,其中男11 865名,女11 981名,分别占总人数的49.76％和50.24％;其中精神分裂症患者124例,精神分裂症调整后终生患病率为5.56‰,时点患病率为5.04‰;农村83例,城市41例;男54例,女70例;受教育程度情况:文盲26例,小学39例,初中47例,高中或中专9例,大专或本科及以上3例;婚姻状态:未婚31例,初婚78例,再婚3例,离婚11例,丧偶1例.单因素分析结果显示,精神分裂症患者在不同受教育水平(x2=33.903,P＜0.01)以及不同婚姻状况中患病率差异均有统计学意义(x2=137.143,P＜0.01).Logistic回归分析显示,城乡(Wald x2=37.296,P＜0.01)、性别(Wald x2=13.131,P＜0.01)、受教育程度(Wald x2=48.338,P＜0.01)、婚姻状态(Wald x2=54.495,P＜0.01)、家族史(Wald x2=107.340,P＜0.01)是精神分裂症患者患病的影响因素.结论 河南省精神分裂症患病率与国内外研究结果基本一致,精神分裂症防治应根据不同地区、不同年龄、不同性别等制定针对性措施.“,”Objective To investigate the morbidity rate,prevalence and influencing factors of schizophrenia among people aged 15 and above in Henan Province.Methods In 2015,a multi-stage stratified random sampling method was adopted,and the revised General Health Questionnaire (GHQ-12) was used as a preliminary screening tool to carry out mental disorder epidemiological investigation in 20 counties of Henan Province.The sampled people were divided into high,medium and low risk groups according to the GHQ-12 scores.The diagnosis of mental disorders was made by attending psychiatrist with DSM-Ⅳ-TR Axis Ⅰ diagnostic clinical interview pattern scale (SCID).The qualitative data were compared by chi-square test,and the influencing factors of schizophrenia were analyzed by Logistic regression analysis.Results A total of 23 846 people were surveyed,including 11 865 (49.76％) men and 11 981 (50.24％) women in which 124 ones were diagnosed with schizophrenia,with the adjusted lifetime prevalence rate of 5.56‰,and time point prevalence of 5.04‰.Of the 124 cases,83 lived in towns and 41 lived in cities,54 were male and 70 were female.The other basic message:level of education:illiterate 26,primary school 39,junior high school 47,high school or technical secondary school 9,junior or regular college 3;marital status:unmarried 31,first marriage 78,remarried 3,divorced 11,widowed 1.Univariate analysis showed statistically significant differences in the prevalence of schizophrenia at different levels of education (x2=33.903,P＜0.01) and marital status (x2=137.143,P＜0.01).Logistic regression analysis showed that urban and rural areas (Wald x2=37.296,P＜0.01),gender (Wald x2=13.131,P＜0.01),education level (Wald x2=48.338,P＜0.01),marital status (Wald x2=54.495,P＜0.01) and family history (Wald x2=107.340,P＜0.01) were the influencing factors of schizophrenia.Conclusion The prevalence rate of schizophrenia in Henan Province is basically consistent with the research results at home and abroad,and the prevention and treatment of schizophrenia should be based on different regions,ages,genders,et al.