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目的:探讨最大颈动脉内膜中层厚度(max-cIMT)与脂蛋白相关磷脂酶A2(Lp-PLA2)活性对冠心病的预测作用。方法:比较冠脉正常组(73例)、稳定性心绞痛组(35例)和急性冠脉综合征(ACS)组(43例)3组患者的基本临床资料、max-cIMT及Lp-PLA2血浆浓度的差异。结果:(1)3组患者间年龄、性别、高血压、他汀服用史等差异无统计学意义,吸烟、糖尿病史及高密度脂蛋白胆固醇(HDL-C)水平差异有统计学意义(P<0.05);(2)max-cIMT与Lp-PLA2活性冠脉正常组最低,ACS组最高(P<0.01);(3)均衡其它危险因素,Lp-PLA2活性、max-cIMT及HDL-C水平与冠心病独立相关(P<0.05);(4)max-cIMT与Lp-PLA2活性诊断冠心病的受试者工作特征曲线之曲线下面积(AUC)分别为0.748与0.85(P<0.01)。结论:max-cIMT及Lp-PIA2活性与冠心病的发生均相关,均可以作为冠心病的危险预测因子。
Objective: To investigate the predictive value of maximum carotid intima-media thickness (max-cIMT) and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity on coronary heart disease. Methods: The clinical data of max-cIMT and Lp-PLA2 plasma in patients with normal coronary artery (73 cases), stable angina pectoris group (35 cases) and acute coronary syndrome group (43 cases) Differences in concentration. Results: (1) There were no significant differences in age, sex, hypertension, statin use history, smoking history, diabetes mellitus and HDL-C levels between the three groups (P < 0.05). (2) The maximal coronary artery activity of max-cIMT and Lp-PLA2 was the lowest in ACS group and the highest in ACS group (P <0.01). (3) The other risk factors, Lp-PLA2 activity, max-cIMT and HDL-C (P <0.05); (4) The area under the curve (AUC) of the working characteristic curves of max-cIMT and Lp-PLA2 activity in patients with coronary heart disease were 0.748 and 0.85 respectively (P <0.01). Conclusion: The max-cIMT and Lp-PIA2 activities correlate with the incidence of coronary heart disease, both of which can be used as predictors of risk of coronary heart disease.