Mesoporous MCM-41 supported Schiff base and Cu SO_4 5H_2 O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines(or aldehydes and amines) to afford pharmaceutically important thiazolidinone derivatives. The catalytic reactions involving twocomponents or three-components afforded the desired product in high yields(up to 98% and 99%).Moreover, the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times. Mesoporous MCM-41 supported Schiff base and Cu SO_4 5H_2 O shows high catalytic activity in the cyclocondensation of mercaptoacetic acid with imines (or aldehydes and amines) to afford essential thiazolidinone derivatives. The catalytic reactions involving twocomponents or three-components afforded the desired product In the high yields (up to 98% and 99%)., the catalyst works well with respect to recyclability, giving the product in 85% and 83% yields after recycling six times.