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目的探讨肝上皮样血管内皮瘤的临床病理特征及诊断要点。方法通过HE切片及免疫组化染色观察1例肝上皮样血管内皮瘤,并结合文献讨论。结果肿瘤由呈树突状和巢状排列的上皮样内皮细胞组成。肿瘤细胞形成胞质内管腔和空泡,内可见红细胞,核偏位,类似印戒样细胞;部分区域肿瘤细胞在血管内形成乳头状、息肉样及出芽状突出物结构。免疫组化示肿瘤细胞CD31和CD34(+)。结论肝上皮样血管内皮瘤是一种低度恶性的血管源性肿瘤,临床少见,易误诊为癌,免疫组化有助于对该病的诊断及鉴别诊断。
Objective To investigate the clinicopathological features and diagnosis points of hepatocellular hemangioendothelioma. Methods One case of hemangioendothelioma of the liver was observed by HE and immunohistochemistry, and the literature was discussed. Results The tumors consisted of epithelial-like endothelial cells that were dendritic and nested. Tumor cells to form the cytoplasm of the lumen and vacuoles, visible red blood cells, nuclear deviation, similar to signet ring-like cells; part of the regional tumor cells in the blood vessels to form papillary, polypoid and bud-like protrusions structure. Immunohistochemistry showed tumor cells CD31 and CD34 (+). Conclusions Hepatic epithelioid hemangioendothelioma is a low grade malignant tumor of vasogenic origin. It is rare in clinical practice and misdiagnosed as carcinoma. Immunohistochemistry is helpful for the diagnosis and differential diagnosis of the disease.