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目的探讨奥曲肽治疗肝硬化食管胃底静脉曲张出血的疗效及安全性。方法回顾性分析三门峡市第三人民医院56例肝硬化食管胃底静脉曲张出血病例资料,将所有病例随机分成两组,治疗组和对照组各28例。在常规治疗(禁食、输液、输血、对症处理)的基础上,治疗组给予奥曲肽注射液以50μg/h的速度连续滴注48~72 h,对照组给予垂体后叶素以0.9 U/min静脉滴注,直至止血后16 h。治疗期间严密观察两组患者生命体征变化及不良反应。结果治疗组与对照组相比,总有效率比较差异有统计学意义(P<0.05);再出血率明显降低(P<0.05);不良反应发生率治疗组明显优于对照组(P<0.05)。结论奥曲肽治疗肝硬化食管胃底静脉曲张出血效果良好,不良反应发生率低,安全可靠,值得临床推广使用。
Objective To investigate the efficacy and safety of octreotide in the treatment of hepatic cirrhosis with esophageal variceal hemorrhage. Methods A retrospective analysis of Sanmenxia Third People ’s Hospital 56 patients with cirrhosis esophageal varices bleeding data, all cases were randomly divided into two groups, the treatment group and the control group of 28 cases. On the basis of routine treatment (fasting, transfusion, transfusion, symptomatic treatment), the treatment group was given octreotide injection 50μg / h continuous infusion of 48 ~ 72 h, the control group was given pituitrin to 0.9 U / min Intravenous drip until 16 h after hemostasis. During the treatment of close observation of two groups of patients with vital signs and adverse reactions. Results Compared with the control group, the total effective rate was significantly different (P <0.05) and the rate of rebleeding was significantly lower (P <0.05). The incidence of adverse reactions in the treatment group was significantly higher than that in the control group (P <0.05) ). Conclusion octreotide treatment of cirrhosis of esophageal varices bleeding effect is good, the incidence of adverse reactions low, safe and reliable, it is worth promoting the use of the clinic.