非整倍体是指在遗传性疾病和恶性肿瘤中DNA和染色体异常和高度含量的状态。20年来流式细胞仪能广泛测定各种临床病理系列的非整倍体情况,多达75％的肿瘤显示非整倍体表现,其价值作为生物学侵袭性的临床标志仍不肯定。需要新技术用以更精确探索组成非整倍体以及人类肿瘤恶性表型的基因和亚染色体变化。 Aneuploidy refers to DNA and chromosomal abnormalities and high levels of status in hereditary diseases and malignancies. For more than 20 years, flow cytometers have been widely used to measure a variety of clinical and pathological series of aneuploidy, with as much as 75% of tumors showing aneuploidy, and their value as a clinical marker of biological invasion remains uncertain. There is a need for new techniques for more accurate exploration of the genetic and sub-chromosomal changes that make up the aneuploidy as well as the malignant phenotype of human tumors.