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目的:观察硫辛酸加丹红注射液治疗早期糖尿病肾病的效果及安全性。方法:选择老年早期糖尿病肾病60例,随机分为观察组和对照组各30例。对照组采用α-硫辛酸治疗,观察组在对照组基础上加用丹红注射液治疗。观察两组治疗前后尿微量清蛋白排泄率(UAER)、D二聚体(D-D)、超敏C反应蛋白(hs-CRP)等指标的变化。结果:治疗后,观察组UAER、D-D、hs-CRP水平均显著低于对照组(P<0.05);两组肌酐(Cr)、尿素氮(BUN)、空腹血糖(FPG)、糖化血红蛋白(HbA1C)、谷丙转氨酶(ALT)、收缩压(SBP)、舒张压(DBP)水平均差异不显著(P>0.05)。观察组输液部位出现轻度皮肤瘙痒1例,降低输液浓度后好转。结论:硫辛酸加丹红注射液降低早期糖尿病肾病UAER、D-D、hs-CRP水平的效果优于单用硫辛酸治疗,且安全。
Objective: To observe the efficacy and safety of lipoic acid and jidanhong injection in the treatment of early diabetic nephropathy. Methods: 60 elderly patients with early diabetic nephropathy were randomly divided into observation group and control group, 30 cases each. The control group was treated with α-lipoic acid. The observation group was treated with Danhong injection on the basis of the control group. The changes of urinary albumin excretion rate (UAER), D-dimer (D-D), hs-CRP and other indexes before and after treatment were observed. Results: After treatment, the levels of UAER, DD and hs-CRP in the observation group were significantly lower than those in the control group (P <0.05). Cr, BUN, FPG, HbA1C ALT, SBP and DBP did not show any significant difference (P> 0.05). One case of mild pruritus occurred in the infusion site of the observation group, which was improved after the infusion concentration was reduced. Conclusions: The effect of lipoic acid-jidanhong injection in reducing the levels of UAER, D-D and hs-CRP in patients with early diabetic nephropathy is better than that with lipoic acid alone and is safe.