论文部分内容阅读
萘丁美酮(Nabumetone)系口服后在体内变为活性代谢物而起作用的前体药物。活性代谢物在人体内的消除半减期长,约1天。动物实验表明,本品对各种炎症模型的抗炎作用虽不如消炎痛,但明显较阿司匹林强,镇痛作用也优于阿司匹林。另外,致溃疡形成作用较消炎痛及阿司匹林弱,对人消化道稍有刺激作用。毒性试验未发现异常。
Nabumetone is a prodrug that acts as an active metabolite in the body after oral administration. Elimination of active metabolites in the human body half-dead long, about 1 day. Animal experiments show that the anti-inflammatory effect of this product on various inflammatory models, although not as indomethacin, but significantly stronger than aspirin, analgesic effect is better than aspirin. In addition, the role of ulcer formation than indomethacin and aspirin weak, slightly stimulate the human digestive tract. Toxicity test found no abnormalities.