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患儿女,3岁8个月。误服芬氟拉明35片,40分钟后入睡,1小时后出现全身抖动,1个半小时后神志不清,双眼凝视,吐沫,四肢僵直舞动,渐转为强直性抽搐约1个半小时,于1993年5月23日急诊入院。经吸氧,先后以冬眠灵、非那根各15mg,安定4mg静脉注射,10%水合氯醛8ml 灌肠,同时用20%甘露醇治疗脑水肿,纠正低血糖,退热,预防感染,保肝治疗。于入院3个半小时抽搐停止,躁动、神志不清持续31小时后完全恢复正常,步态蹒跚、言语不清4天半恢复正常。芬氟拉明药理作用是使下丘脑和间脑区释放5-羟色胺,并阻断5-羟色胺的再摄取,能加速外周组织对葡萄糖的摄取,使血糖浓度降低。近年来多用于治疗单纯性肥胖症,剂量过大可引起抽搐。
Children with children, 3 years and 8 months. Ffenfluramine 35, 40 minutes after falling asleep, 1 hour after the whole body shaking, an hour and a half after the unconscious, his eyes staring, spittle, limbs stiff galloping, gradually turning to tonic twitch about 1 and a half hours , Was admitted to the emergency department on May 23, 1993. After oxygen inhalation, successively with winter sleep Ling, finagen each 15mg, stability 4mg intravenous injection, 10% chloral hydrate 8ml enema, while 20% mannitol treatment of cerebral edema, to correct hypoglycemia, fever, prevent infection, liver protection treatment. 3 and a half hours after admission convulsions stopped, restlessness, confusion continued for 31 hours after the full return to normal, staggering gait, verbose 4 days and a half returned to normal. Fenfluramine pharmacological effect is to release serotonin in the hypothalamus and diencephalon and block the reuptake of serotonin, can accelerate the peripheral tissues of glucose uptake, so that blood glucose levels decreased. In recent years, more for the treatment of simple obesity, overdose can cause convulsions.