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目的：探讨唾液酸在喉鳞状细胞癌中的表达和意义。方法：应用免疫组织化学技术观察了１４例喉鳞癌、８例癌旁非典型增生组织以及３例正常喉粘膜上皮内两种凝集素ＳＮＡ和ＭＡＡ的表达和分布。结果：喉鳞状上皮细胞在增生、转化和恶变过程中，细胞质中ＳＮＡ表达增强（Ｐ≤０．０５）。但ＳＮＡ和ＭＡＡ的表达和分布与喉鳞癌的Ｔ分类及Ｎ分类之间无统计学意义（Ｐ≥０．０５）。结论：喉鳞癌细胞质中ＳＮＡ的特异结合糖、α２－６结合型唾液酸可能是喉鳞癌一种重要标志，与喉鳞癌的分化增殖有关。但α２－６结合型唾液酸变化与喉鳞癌局部浸润程度和颈淋巴结转移无关。
Objective: To investigate the expression and significance of sialic acid in laryngeal squamous cell carcinoma. Methods: Immunohistochemical technique was used to observe the expression and distribution of SNA and MAA in 14 cases of laryngeal squamous cell carcinoma, 8 cases of adjacent atypical hyperplasia tissues and 3 cases of normal laryngeal mucosal epithelium. Results: The expression of SNA in cytoplasm was enhanced in laryngeal squamous epithelial cells during proliferation, transformation and malignant transformation (P≤0.05). However, the expression and distribution of SNA and MAA had no statistical significance between T classification and N classification of laryngeal squamous cell carcinoma (P> 0.05). Conclusion: SNA-specific carbohydrate and α2-6-linked sialic acid in the cytoplasm of laryngeal squamous cell carcinoma may be an important sign of laryngeal squamous cell carcinoma, which is related to the differentiation and proliferation of laryngeal squamous cell carcinoma. However, the changes of α2-6-associated sialic acid were not associated with the degree of local invasion of laryngeal squamous cell carcinoma and cervical lymph node metastasis.