血管内皮生长因子(VEGF)是一种同源二聚体糖蛋白,是血管内吱细胞高度特异的有丝分裂原,能诱导内皮细胞增殖,刺激内皮细胞迁移并抑制细胞凋亡等.VEGF参与排卵、子宫内膜周期性变化、胚胎植入及胚胎发育等多种雌性生殖过程.对先兆子痫和胎儿宫内发育迟缓等生殖疾病发生也起着重要作用.结合本实验室多年来对雌性生殖过程中血管发生及其相关因子的研究,综述了VEGF在雌性生殖系统中的怍用,并展望其研究和应用前景. Vascular endothelial growth factor (VEGF) is a homodimeric glycoprotein, which is a highly specific mitogen of vascular squeak cells, which can induce endothelial cell proliferation, stimulate endothelial cell migration and inhibit apoptosis, etc. VEGF is involved in ovulation, Endometrial cyclical changes, embryo implantation and embryo development and other reproductive processes of the female reproductive diseases such as pre-eclampsia and intrauterine growth retardation also plays an important role in combination with the laboratory over the years of female reproductive processes In angiogenesis and related factors, reviewed the use of VEGF in the female reproductive system, and its prospects for research and application.