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目的:观察不同阻断时间对体外循环期间血浆脂质过氧化物丙二醛(MDA)和红细胞内超氧化物歧化酶(SOD)的影响.方法:选择29例体外循环下心内直视手术病人,根据阻断主动脉时间分为3组,第一组:阻断主动脉时间＜30MIN,共12例;第二组:阻断主动脉时间30~60MIN,共10例:第三组:阻断主动脉时间＞60MIN,共7例.分别在手术前、转流5MIN时、开放主动脉时、停体外循环时、停体外循环后1H,经桡动脉采血5ML.血清MDA采用硫代巴比妥酸(TBA)法测定,SOD采用亚硝酸盐法.结果:第一组体外循环开始后,SOD即下降,开放主动脉时SOD明显下降,一直持续到术后(P＜0.05);第二组在开放主动脉时SOD下降明显约为30％(P＜0.01),一直持续到术后(P＜0.01);第三组变化同第二组,但SOD下降的程度更明显.第一组体外循环开始后,MDA变化不明显(P＞0.05);第二组在开放主动脉时MDA明显增加P＜0.05),一直持续到术后1H(P＜0.01);第三组在转流前及开放主动脉时变化同第二组,MDA增加的程度更明显.而且随着阻断时间的延长MDA随之增加.结论:随着阻断时间的延长,MDA随之增加,SOD随“,”Objective:To investigate the effects of ischemia time on plasma malondialdehyde (MDA) and superoxide dismutase(SOD) during cardiopulmonary bypass (CPB).Methods:Twenty nine patients undergoing open heart surgery were assigned into three groups:group I (?n?=12) inchemia time60 min.Plasma MDA were measured by thiobarbituric acid (TBA) method, SOD were measured by nitrite method. [WT5”HZ〗Results:[WT5”BZ〗Plasma MDA increased gradually be...