急性肾功能衰竭(acute renal failure,ARF)是临床危重疾病,其死亡率从19世纪60年代至今保持不变,仍高达50～60%,且有50%的存活病例遗留不同程度的慢性肾功能损害[1]。ARF是由缺血和毒素单独或联合原因造成的,缺血性约占ARF50%[2]。目前,国内外还没有一种有效防治缺血性急性肾功 Acute renal failure (ARF) is a critically ill clinical disease whose mortality rate has remained as high as 50-60% since the 1960s to the present and 50% of the surviving cases left some degree of chronic renal function Damage [1]. ARF is caused by ischemia and toxins, either alone or in combination, and ischaemia accounts for about 50% of ARF [2]. At present, there is no effective prevention and treatment of ischemic acute renal failure both at home and abroad