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目的探讨丙戊酸钠(VPA)治疗中风后癫痫患者的临床疗效。方法中风后癫痫患者随机平均分为两组,对照组采用普通治疗方法,观察组则在普通治疗的基础上加用口服丙戊酸钠药物治疗,治疗后进行随访,比较两组患者的临床疗效和治疗前后体重、BMI、血糖、胰岛素抵抗指数变化。结果观察组治疗后发作率低于对照组,差异有统计学意义(P<0.05);观察组治疗后体重、BMI、胰岛素抵抗指数变化均较治疗前有所增加(P<0.05),而血糖值无明显变化(P>0.05)。结论VPA治疗可引起癫痫患者体重、BMI、血清胰岛素水平增高,并导致胰岛素抵抗,但对其血糖无直接影响;丙戊酸钠负荷量治疗中风后癫痫患者控制效果较满意,且未发现比较明显的药物不良反应,值得临床进一步推广和应用。
Objective To investigate the clinical efficacy of valproate (VPA) in patients with epilepsy after stroke. Methods Patients with epilepsy after stroke were randomly divided into two groups randomly. The control group was treated by ordinary method. The observation group was treated with oral sodium valproate on the basis of general treatment. After treatment, the patients were followed up, and the clinical efficacy was compared between the two groups And before and after treatment body weight, BMI, blood glucose, insulin resistance index changes. Results After the treatment, the attack rate in the observation group was lower than that in the control group (P <0.05). The changes of body weight, BMI and insulin resistance index in the observation group were higher than those before treatment (P <0.05) No significant change in value (P> 0.05). Conclusions VPA treatment can cause the body weight, BMI and serum insulin levels of epileptic patients to increase, leading to insulin resistance, but not to its blood glucose. VPA treatment is more satisfactory for treating patients with epilepsy after stroke and has not been found obvious Of the adverse drug reactions, it is worth further clinical application and application.