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目的 :研究α转化生长因子 (TGFα)及其受体表皮生长因子受体 (EGFR)在乳腺癌中的表达特点 ,以及两者间的相互作用。并通过与已知预后因素的相关分析 ,研究它们各自在肿瘤发展中的作用。方法 :对 84例导管浸润型乳腺癌标本进行TGFα EGFR免疫组织化学双重标记 ,同时观察两者在非肿瘤及肿瘤组织的表达 ,并对结果进行单变量和多变量统计学分析。结果 :TGFα和EGFR在癌旁组织上皮细胞中均有表达 ,分别在 76 2 %和17 8%浸润癌细胞中表达 ,在 16 7%浸润癌细胞中同时表达。χ2 分析显示TGFα在浸润癌细胞中的表达只与ER阴性相关联 ,而EGFR的表达则与大体积肿瘤、炎性乳癌、腋窝淋巴结受累、不良肿瘤组织学分级 (SBRⅢ级 )以及雌孕激素受体阴性相关联。多变量统计分析显示 ,浸润癌细胞中TGFα的表达与炎性乳癌相关联 (P =0 0 48) ,而EGFR的表达则与雌激素受体阴性相关联 (P =0 0 0 2 )。结论 :TGFα和EGFR在乳腺癌组织中的表达与在非肿瘤组织中明显不同 ,并与乳腺癌不良愈后因素相关联 ,提示他们在乳腺癌的发展中起着重要作用。
Objective: To investigate the expression of α-transforming growth factor (TGF-α) and its receptor epidermal growth factor receptor (EGFR) in breast cancer and its interaction. And through their correlation with known prognostic factors to study their respective roles in tumor development. Methods: 84 cases of invasive ductal infiltrating breast cancer specimens were immunohistochemically labeled with TGFα EGFR, and their expressions in non-tumor and tumor tissues were observed. Univariate and multivariate statistical analyzes were performed on the results. Results: Both TGFα and EGFR were expressed in the paracancerous tissue epithelial cells, which were expressed in 76 2% and 17 8% infiltrating carcinoma cells and simultaneously in 16 7% infiltrating carcinoma cells. χ2 analysis showed that the expression of TGFα in infiltrating cancer cells was only associated with ER negative, while the expression of EGFR was associated with large volume tumors, inflammatory breast cancer, axillary lymph node involvement, poor histological grade (SBR Ⅲ) and estrogen and progesterone Negative correlations. Multivariate statistical analysis showed that the expression of TGFα was correlated with inflammatory breast cancer in invasive cancer cells (P = 0 0 48), whereas the expression of EGFR was associated with negative estrogen receptor (P = 0.002). CONCLUSION: The expression of TGFα and EGFR in breast cancer tissues is significantly different from that in non-tumorous tissues, and is associated with poor prognosis of breast cancer, suggesting that they play an important role in the development of breast cancer.