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目的：探讨利用母血胎儿有核红细胞进行性连锁遗传病产前诊断的可行性；方法：通过密度梯度离心富集母血胎儿有核红细胞，并经流式细胞仪鉴定，对富集后胎儿有核红细胞进行了ＳＲＹ 基因的套式ＰＣＲ检测；结果：５ 例有性连锁遗传病家族史的孕妇外周血中经扩增后３ 例阳性、２ 例阴性，所得结果均得到相应羊水、胎盘ＤＮＡＳＲＹ／ＰＣＲ 检测或出生胎儿生殖器检查结果的证实；结论：母血中胎儿有核红细胞可用于性连锁遗传病的早期产前诊断
OBJECTIVE: To explore the feasibility of prenatal diagnosis of maternal-fetal fetal hereditary erythrocytes with inherited genetic disease. Methods: Enrichment of fetal erythrocytes in maternal blood was performed by density gradient centrifugation and identified by flow cytometry. 3 cases of peripheral blood of 5 pregnant women with sexual intercurrent genetic disease were positive after amplification and 2 cases were negative. The results obtained were the corresponding amniotic fluid, placental DNASRY / PCR test or the results of fetal genital examination confirmed; Conclusion: maternal blood cells in the nucleated red blood cells can be used for genetic diagnosis of sexually transmitted diseases early prenatal diagnosis