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目的综述国内外抗MRSA(耐甲氧西林金黄色葡萄球菌)天然产物的研究进展。方法查阅关于抗MRSA天然产物的国内外文献。结果共计报道抗MRSA天然产物约85个,其中58个来源于微生物,26个来源于植物,另外1个来源于海洋动物海绵;主要包括环肽类、生物碱类、萜类、醌类、黄酮类和大环内酯类等结构类型,其中11个化合物含有氯、溴或硫元素;30个化合物体外抗MRSA的MIC<5μg.mL-1。结论微生物和植物的次级代谢产物中含有结构特异、活性显著的抗MRSA成分,随着临床上耐药病原菌不断地被分离发现和防治MRSA感染形势的日趋严峻,有必要对微生物和植物的抗MRSA成分展开广泛而又深入的研究。
Objective To summarize the research progress of anti-MRSA (methicillin-resistant Staphylococcus aureus) natural products at home and abroad. Methods Refer to domestic and foreign literature on anti-MRSA natural products. Results A total of 85 anti-MRSA natural products were reported, of which 58 were from microorganisms, 26 from plants and one from marine animal sponges. They mainly included cyclic peptides, alkaloids, terpenes, quinones and flavonoids 11 kinds of compounds contain chlorine, bromine or sulfur element; 30 compounds in vitro anti-MRSA MIC <5μg.mL-1. Conclusion The secondary metabolites of microorganisms and plants contain structurally specific and active anti-MRSA components. With the continuous isolation of clinical isolates of pathogenic bacteria and the increasing severity of MRSA infection, it is necessary to evaluate the antimicrobial activity of microorganisms and plants MRSA component to conduct a wide range of in-depth research.