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端粒与细胞衰老和肿瘤发生密切相关。本文综述端粒合成的两种途径:端粒酶途径和重组途径,并说明两种途径均受端粒蛋白调控。提出端粒蛋白有望成为继端粒酶之后新的肿瘤诊断和治疗靶点。
Telomere is closely related to cell senescence and tumorigenesis. This article reviews two approaches to telomere synthesis: the telomerase pathway and the recombination pathway, and suggests that both approaches are regulated by telomere. Proposed telomere protein is expected to become a new tumor diagnostic and therapeutic target after telomerase.