谷氨酰胺(Gln)一般被认为是非必需氨基酸,但在应激状态下,因机体对Gln的需要超过其合成能力,它可能是必需的。另外,Gln还是一种免疫营养素。补充Gln可以防止细菌移位,维持肠黏膜屏障,对胃肠道免疫功能有调节作用。早产儿尤其是极低出生体质量儿补充Gln可以减少院内感染的发生,提高其对胃肠道喂养的耐受性,缩短肠外营养的时间,减少住院时间等。 Glutamine (Gln) is generally considered a nonessential amino acid, but under stress it may be necessary due to the body’s need for Gln beyond its capacity to synthesize. In addition, Gln is an immune nutrient. Gln supplement can prevent bacterial translocation, maintain the intestinal mucosal barrier, regulate the immune function of the gastrointestinal tract. Preterm infants, especially those with very low birth weight, can reduce the incidence of nosocomial infections, improve their tolerance to gastrointestinal feeding, shorten the time for parenteral nutrition and reduce the length of hospital stay.