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目的建立三层共挤输液用袋中抗氧剂四(2,4-二叔丁基酚)-4,4-联苯基二亚磷酸酯(PEPQ)的含量测定法。方法采用Dikma Diamonsil C18色谱柱(250 mm×4.6 mm,5μm),流动相为乙腈-四氢呋喃(80∶20),柱温30℃,检测波长270 nm。结果抗氧剂PEPQ在0~200.0μg·m L?1内呈良好的线性关系(r=0.999),抗氧剂PEPQ回收率为92.3%(RSD=1.97%)。结论该方法准确、灵敏、简便,适用于测定三层共挤输液用袋中抗氧剂PEPQ的含量。
OBJECTIVE To establish a method for the determination of tetra (2,4-di-tert-butylphenol) -4,4-diphenyl diphosphite (PEPQ) in a three-layer co-extrusion infusion bag. Methods The Dikma Diamonsil C18 column (250 mm × 4.6 mm, 5 μm) was used. The mobile phase consisted of acetonitrile and tetrahydrofuran (80:20). The column temperature was 30 ℃ and the detection wavelength was set at 270 nm. Results The antioxidant PEPQ showed a good linearity (r = 0.999) in the range of 0 ~ 200.0μg · m L -1, and the recovery rate of PEPQ was 92.3% (RSD = 1.97%). Conclusion The method is accurate, sensitive and simple and is suitable for the determination of the antioxidant PEPQ in the three-layer coextrusion infusion bag.