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本文对10只孕7天(胚泡着床后2天)大鼠宫腔内一次性注入醋酸棉酚完全抗早孕后再次生育的子代,及8只孕鼠宫腔内一次注入醋酸棉酚部分抗早孕后产出的子代(F_1),及由此子代繁殖的孙代鼠(F_2),进行骨髓细胞染色体畸变率及胎肝血细胞微核率检测。结果表明,用醋酸棉酚抗早孕后再生育的F_1及用药后部分抗孕产出的F_1及F_2,与对照组相比,均无显著差异(P>0.05)。表明醋酸棉酚作为宫内一次性抗生育药物作用后对后代是安全的。
In this paper, 10 pregnant 7 days (blastocyst 2 days after implantation) rat intrauterine injection of ginsenoside completely anti pregnancy after childbirth again offspring, and 8 pregnant rats intrauterine injection of gossypol acetate Part of the progeny (F_1) produced after anti-first trimester and the offspring of the offspring (F_2) were used to detect the chromosome aberration rate and the micronucleus rate of fetal liver blood cells. The results showed that there was no significant difference (P> 0.05) between F_1 and F_2 produced by ginsenoside after anti-premature pregnancy and some anti-pregnancy F_1 and F_2 after pregnancy. Show gingivalid acetate as a one-time intrauterine anti-fertility drug effect on future generations is safe.