目的　研究免疫球蛋白 (Ig)轻链kappa(Igκ)和lambda(Igλ)在胃癌细胞中的表达状况 ,以及Igκ和Igλ在胃癌细胞中表达的一致性。方法　运用免疫组织化学技术LSAB法对 2 2例石蜡包埋人胃癌组织标本Igκ和Igλ进行检测。结果　在 2 2例胃癌组织中 ,胃癌细胞内Igκ和Igλ均阳性者 17例 ,占 77.3% ;仅Igκ阳性者 2例 ,占 9.1% ;仅Igλ阳性者 1例 ,占 4 .5 % ;两者均阴性者 2例 ,占 9.1%。结果显示 ,胃癌细胞内Igκ和Igλ两者的表达关系密切 (χ2 =5 .4 898,P <0 .0 5 )。结论　胃癌细胞中同时有两种类型免疫球蛋白轻链 (Igκ和Igλ)表达 ,提示其可能有不同于B淋巴细胞的Ig基因活化机制 Objective To study the expression of immunoglobulin (Ig) light chain kappa (Igκ) and lambda (Igλ) in gastric cancer cells and the consistency of Igκ and Igλ in gastric cancer cells. Methods Immunohistochemical technique was used to detect Igκ and Igλ in 22 paraffin-embedded human gastric cancer specimens by LSAB method. Results In 22 gastric cancer tissues, 17 cases were positive for Igκ and Igλ in gastric cancer cells, accounting for 77.3%; only 2 cases were Igκ positive, accounting for 9.1%; only 1 was positive for Igλ, accounting for 4.5% Two were negative, accounting for 9.1%. The results showed that Igκ and Igλ expression in gastric cancer cells are closely related (χ2 = 5.5898, P <0.05). Conclusion There are two types of immunoglobulin light chain (Igκ and Igλ) expression in gastric cancer cells at the same time, suggesting that they may have different Ig gene activation mechanism from B lymphocytes