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目的探讨尿TGF-β1在慢性肾功能衰竭(CRF)不同阶段的变化规律、作用及临床意义。方法采用ELISA方法测定60例不同阶段CRF患者和16例正常人尿TGF-β1水平。结果CRF患者尿TGF-β1高于正常人。Ⅰ、Ⅱ、Ⅲ期CRF患者尿TGF-β1随肾损害加重逐渐升高,而Ⅳ期CRF患者尿TGF-β1有下降趋势,与血清肌酐呈分离现象。结论CRF患者尿TGF-β1可作为反映肾损害程度的一个敏感性指标,有助于评价CRF的发生发展以及肾脏纤维化水平,同时对CRF的诊断和治疗具有指导意义。
Objective To investigate the changes and clinical significance of urinary TGF-β1 in different stages of chronic renal failure (CRF). Methods Urinary TGF-β1 levels in 60 cases of CRF patients and 16 normal controls were measured by ELISA. Results Urinary TGF-β1 in CRF patients was higher than that in normal people. The urinary TGF-β1 in patients with stage Ⅰ, Ⅱ, and Ⅲ CRF increased gradually with the increase of renal injury, while the level of urinary TGF-β1 in stage Ⅳ CRF decreased with serum creatinine. Conclusion Urinary TGF-β1 in CRF patients can be used as a sensitive index to reflect the degree of renal damage. It is helpful to evaluate the occurrence and development of CRF and the level of renal fibrosis in CRF patients. At the same time, it is instructive for the diagnosis and treatment of CRF.