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目的：探讨肝硬化患者胰岛素抵抗及胰岛素分泌功能和糖代谢的改变。方法：对３０例肝硬化患者和２６例正常人进行口服葡萄糖耐量及胰岛素释放试验，以Ｈｏｍａ模型计算胰岛素抵抗指数（ＩＲＩ）及胰岛β细胞功能指数（ＨＢＣＩ），并对结果进行分析。结果：肝硬化组糖耐量较对照组显著降低（Ｐ＜００１），血清胰岛素水平增高，并呈现释放延迟，ＩＲＩ及ＨＢＣＩ指数高于对照组。结论：肝硬化患者存在胰岛素抵抗、肝源性糖耐量异常及内源性高胰岛素血症或胰岛素释放延迟，与肝功能损害有关。
Objective: To investigate the changes of insulin resistance, insulin secretion and glucose metabolism in cirrhotic patients. Methods: 30 patients with cirrhosis and 26 normal subjects were tested for oral glucose tolerance and insulin release. The IRI and HBCI were calculated with Homa model and the results were analyzed. Results: Compared with the control group, the impaired glucose tolerance of the cirrhosis group was significantly lower (P <001), the level of serum insulin was increased, the delay of release was found, and the indexes of IRI and HBCI were higher than those of the control group. Conclusion: Patients with liver cirrhosis have insulin resistance, abnormal hepatic glucose tolerance and endogenous hyperinsulinemia or delayed insulin release, which is associated with impaired liver function.