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目的:探讨白塞病患者的抑郁焦虑状况及其影响因素。方法:连续收集住院白塞病患者142例的基本信息和临床资料，选择我院同一周期体检健康的志愿者作为对照组。采用抑郁、焦虑自评量表分别指导患者自评。采用n t检验、方差分析、n χ2检验、Logistic回归分析对数据进行统计。n 结果:①142例白塞病患者抑郁、焦虑和抑郁合并焦虑发生率分别为36.6%（52/142）、31.7%（45/142）、23.2%（33/142）。②社会因素分析：抑郁组和非抑郁组在就业情况、收入水平、医疗保险类型中差异有统计学意义（n χ2=8.020、n χ2=15.489、n χ2=35.712，n P<0.05）；焦虑与非焦虑组在收入水平、医疗保险类型中差异有统计学意义（n χ2=7.288、n χ2=29.376，n P<0.05）。居住在农村、低收入水平、自费医疗是白塞病抑郁的危险因素（n B=-1.787、n B=-0.697、n B=1.931，n P<0.05）；自费医疗是白塞病焦虑的危险因素（n B=2.132，n P<0.05）。③临床因素分析：抑郁组眼损害所占比例较高，2组间差异有统计学意义（n χ2=7.450，n P<0.05），焦虑组消化道受累所占比例较高，2组间差异有统计学意义（n χ2=4.872，n P<0.05）。BDCAF与EMRAI评分均与抑郁评分呈正相关（n r=0.245，n P<0.05；n r=0.265，n P<0.05）；亦均与焦虑评分呈正相关（n r=0.385，n P<0.05；n r=0.388，n P<0.05）。白塞病皮肤黏膜病变活动与抑郁焦虑评分均呈正相关（n r=0.333、n r=0.502，n P<0.05）。④外周血分析：血清CRP、IL-6水平与抑郁评分呈正相关（n B=0.213，n P<0.05；n B=0.483，n P<0.05）；血清CRP水平与焦虑评分呈正相关（n B=0.158，n P<0.05）。n 结论:白塞病患者抑郁、焦虑发生率较健康人群高；白塞病活动期，眼、消化道受累的患者容易产生抑郁焦虑情绪；血清CRP、IL-6水平与抑郁焦虑评分呈正相关。“,”Objective:To survey the incidence of depression and anxiety in patients with Beh?et's disease (BD) and its related factors.Methods:The information and clinical data of 142 inpatients with BD were continuously collected. Volunteers for physical check-up in the hospitalduring the same time periodwere-selected as the control group. Self-rating Depression Scale and Self-rating Anxiety Scale was used to assess the presence and severity of depression and anxiety. Data were statistically analyzed by n t test, one-way analysis of variance, chi-square test, and logistic regression analysis.n Results:① The incidence of depression, anxiety and depression combined with anxiety of 142 BD patientswas 36.6%(52/142), 31.7%(45/142), and 23.2% (33/142), respectively. ② Social factors: The depression and non-depression group had statistically significant differences in employment, in-come level, and medical insurance type (n χ2=8.020, n χ2=15.489; n χ2=35.712, n P<0.05); the anxiety and non-anxiety group were significantly different in income level and medical insurance type (n χ2=7.288, n χ2=29.376, n P<0.05). Living in rural areas, low income levels, and self-paidwererisk factors for depression (n B=-1.787, n P<0.05;n B=-0.697, n P<0.05;n B=1.931, n P<0.05); medical insurance was a risk factor for anxiety (n B=2.132, n P<0.05). ③Clinical factors: The rate of depression in patients with eye inflammation and the rate of anxiety in patients with gastrointestinal involvement were significantly higher than patients without (n χ2=7.450, n P=0.006; n χ2=4.872, n P=0.027). Both Beh?et′s Disease Current Activity Form (BDCAF) and Electronic Medical Record-based Activi-ty Index (EMRAI) scores were positively correlated with depression scores (n r=0.245, n P=0.003; n r=0.265, n P=0.001) and anxiety scores (n r=0.385, n P<0.01;n r=0.388, n P<0.01). BD related skin and mucous membrane involve-mentswere positively correlated with depression and anxiety scores (n r=0.333, n P<0.01;n r=0.502, n P<0.01). ④ Serum C-reactive protein (CRP) and interleukin (IL)-6 levels were positively correlated with depres-sion scores (n B=0.213, n P=0.017; n B=0.483, n P=0.043); serum CRP levels were positively correlated with anxiety scores (n B=0.158, n P=0.032).n Conclusion:The incidence of depression and anxiety in BD patients is higher than that in clinically healthy population. BD Patients with eye damage and gastrointestinal involvement during activie disease stage are prone to have depression and anxiety. Serum CRP and IL-6 levels are positively correlated with depression and anxiety score.