结直肠癌(CRC)是消化道最常见的恶性肿瘤之一,临床早期诊断率低,多数患者出现明显症状时已处于中晚期,综合治疗手段总体治疗效果及预后较差。早期诊断对CRC患者治疗及预后判断尤为重要。循环肿瘤标记物包括循环肿瘤细胞(CTC)、循环游离DNA(cf DNA)、外泌体及循环微小RNA(mi RNA)等,其在化疗方案选择、疗效评估、预后判断等方面具有巨大潜力,引起广泛关注。本文综述循环肿瘤标记物在临床CRC中的应用进展。 Colorectal cancer (CRC) is one of the most common malignant tumors of the digestive tract. The early diagnosis rate of colorectal cancer is low. Most patients have been in the advanced stage when the obvious symptoms appear. The overall treatment effect and prognosis of the comprehensive treatment are poor. Early diagnosis of CRC patients with treatment and prognosis is particularly important. Cyclic tumor markers include circulating tumor cells (CTCs), circulating free DNA (cf DNA), exosomes, and circulating miRNAs (miRNAs) that have great potential for choice of chemotherapeutic regimens, efficacy evaluation, prognostic judgment, Caused widespread concern. This article reviews the application of circulating tumor markers in clinical CRC.