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目的观察姑息化疗联合姑息手术治疗Ⅳ期胃癌患者的治疗效果及安全性。方法选取2014年1月~2014年10月收治的100例Ⅳ期胃癌患者作为研究对象,并随机分为干预组和对照组,每组各50例。对照组患者采用姑息化疗,干预组患者采用姑息化疗结合姑息手术治疗。观察两组患者生存时间、生存质量情况和治疗不良反应情况的差异,评价姑息化疗联合姑息手术的治疗效果。结果干预组患者生存情况明显优于对照组,差异有统计学意义(P<0.05),干预组患者生存质量情况明显优于对照组,差异有统计学意义(P<0.05),干预组患者与对照组患者化疗不良反应和并发症发生率差异无统计学意义(P>0.05)。结论姑息化疗联合姑息手术治疗可以显著提高Ⅳ期胃癌患者治疗效果,值得临床推广应用。
Objective To observe the effect and safety of palliative chemotherapy combined with palliative surgery for patients with stage Ⅳ gastric cancer. Methods A total of 100 patients with stage Ⅳ gastric cancer admitted from January 2014 to October 2014 were selected as study subjects and randomly divided into intervention group and control group with 50 cases in each group. Patients in the control group were treated with palliative chemotherapy. Patients in the intervention group were treated with palliative chemotherapy combined with palliative surgery. The differences of survival time, quality of life and adverse reactions in the two groups were observed to evaluate the effect of palliative chemotherapy combined with palliative surgery. Results The survival of patients in the intervention group was significantly better than that of the control group (P <0.05), and the quality of life in the intervention group was significantly better than that of the control group (P <0.05) There was no significant difference in the incidence of adverse reactions and complications among the control group patients (P> 0.05). Conclusion Palliative chemotherapy combined with palliative surgery can significantly improve the therapeutic effect of patients with stage Ⅳ gastric cancer, which is worthy of clinical application.