自 2 0 0 1年 8月 8日因发生严重肌溶解从市场上撤出西伐他汀以来 ,人们对他汀类药长期应用的安全性给予极大关注。时隔 1年 ,美国心脏病学会于 2 0 0 2年 8月 2 0日在美国《循环》上发布了他汀类药使用及其安全性的临床忠告 ,提出了他汀类药使用的最新建议[1] 。鉴于近年来他 Since the withdrawal of simvastatin from the market on August 8, 2001, due to severe muscle lysis, great attention has been given to the long-term safety of statins. A year later, the American College of Cardiology published clinical advice on the use and safety of statins in the United States on August 20, 2002, and proposed the latest recommendations on the use of statins [ 1] . In view of him in recent years