论文部分内容阅读
目的:对本地区孕妇人群进行不规则抗体的筛查并探讨其阳性率及分布情况,以降低和避免溶血性输血反应的发生,提高输血安全。方法:选取2010-2014年武汉地区66013例住院孕妇的血清,采用微柱凝胶法进行不规则抗体检测,并对阳性标本进一步做抗体特异性、免疫球蛋白类型的鉴定和效价的检测。结果:在66013例孕妇血清中共检测出不规则抗体230例(阳性率0.35%),抗-E 91例、抗-M 31例、其中抗-D 19例、抗-Lea 15例、抗-c13例、抗-Ec 5例、抗-Fya 2例、抗-s 2例、抗-A1 1例、其他抗体(含自身抗体)51例。结论:不规则抗体筛查对孕妇再次怀孕、及时为孕妇寻找相合血液、保证孕妇输血安全、降低孕妇免疫性溶血性输血反应及预防和减少新生儿溶血病的发生有着十分重要的意义。
OBJECTIVE: To screen for irregular antibodies in pregnant women in this region and to explore the positive rate and distribution of hemoglobin in order to reduce and avoid the occurrence of hemolytic transfusion reactions and improve the safety of blood transfusion. Methods: The serum samples of 66013 hospitalized pregnant women in Wuhan from 2010 to 2014 were selected. The irregular antibodies were detected by microcolumn gel method. The positive samples were further identified by antibody specificity, immunoglobulin type and titer. Results: There were 230 cases of irregular antibody (positive rate 0.35%), anti-E 91 cases and anti-M 31 cases, including anti-D 19 cases, anti-Lea 15 cases and anti-c13 5 cases of anti-Ec, 2 cases of anti-Fya, 2 cases of anti-s, 1 case of anti-A1 and 51 cases of other antibodies (including autoantibodies). CONCLUSION: Irregular antibody screening is very important for pregnant women to get pregnant again, find suitable blood for pregnant women in time, ensure blood transfusion safety in pregnant women, reduce immune hemolytic transfusion reaction in pregnant women and prevent and reduce neonatal hemolytic disease.