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目的:探讨直链烷基修饰对Gd-DTPA稳定性和水质子弛豫性能的影响。方法:采用配位竞争法测定钆螯合物的稳定常数,采用反转恢复法测定钆螯合物的水质子弛豫时间。结果:Gd-α-癸基-DTPA和Gd-α-十四烷基-DTPA的稳定常数(lg K)分别为22.80和22.75,生理PH条件下对水质子的弛豫率(R1)分别为4.86和4.78。结论:与母体化合物(Gd-DTPA)比较,Gd-α-癸基-DTPA和Gd-α-十四烷基-DTPA仍保持高稳定性和强的水质子弛豫性能。
Objective: To investigate the effect of linear alkyl modification on the stability of Gd-DTPA and water proton relaxation. Methods: The stability constants of gadolinium chelates were determined by the coordination competition method, and the water proton relaxation time of gadolinium chelates was determined by inversion recovery method. Results: The stability constants (lg K) of Gd-α-decyl-DTPA and Gd-α-tetradecyl-DTPA were 22.80 and 22.75 respectively. The relaxation rates (R1) to water proton at physiological pH were 4.86 and 4.78. Conclusion: Compared with Gd-DTPA, Gd-α-decyl-DTPA and Gd-α-tetradecyl-DTPA still maintain high stability and strong water proton relaxation properties.