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目的：研究缺血再灌流损伤脊髓血流量的变化及其与脊髓病理改变间的关系。方法：20只成年日本大耳白家兔随机分为对照组、缺血30min组、缺血60min组和缺血90min组，用氢清除法测定脊髓血流量（SCBF），尼氏染色观察受损脊髓病理变化。结果：完全缺血时SCBF为0ml·100g-1·min-1，再灌流过程中各组SCBF较缺血时有不同程度的恢复，但较伤前仍有不同程度的下降，并以缺血60min、90min组下降明显；脊髓病理改变以灰质受损最明显，病变严重程度为缺血90min组＞缺血60min组＞缺血30min组＞对照组。结论；缺血时间越长，再灌流后SCBF下降越明显，病理损害也越重。
Objective: To study the changes of spinal cord blood flow in ischemia-reperfusion injury and its relationship with pathological changes of spinal cord. Methods: Twenty adult Japanese white rabbits were randomly divided into control group, 30 min ischemia group, 60 min ischemia group and 90 min ischemia group. Spinal cord blood flow (SCBF) was measured by hydrogen scavenging method and Nissl staining was observed Pathological changes of the spinal cord. Results: SCBF was 0ml · 100g-1 · min-1 at the time of complete ischemia. The SCBF of each group recovered to different degrees after reperfusion compared with that of ischemia, 60min, 90min group decreased significantly; pathological changes to gray matter damage the most obvious lesions severity of ischemic 90min group> ischemia 60min group> ischemia 30min group> control group. Conclusion: The longer the ischemic time is, the more obvious the decline of SCBF is and the heavier the pathological damage after reperfusion.