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目的:探讨甘草泻心汤与美沙拉嗪联合治疗溃疡性结肠炎(UC)的临床疗效及对患者血清炎症细胞因子的影响。方法:将88例UC(寒热错杂型)患者随机分为观察组与对照组,每组44例。对照组给予美沙拉嗪缓释颗粒口服,1.0 g/次,4次/天;观察组在对照组基础上加用甘草泻心汤。两组疗程均为2个月,比较两组临床疗效及血清炎症指标变化。结果:观察组临床疗效总有效率、中医证候疗效总有效率均显著高于对照组(P<0.05);治疗后观察组中医证候积分、Baron评分及血清TNF-α、IL-8、IL-17、IL-23显著低于对照组(P<0.05),IBDQ评分及血清IL-10显著高于对照组(P<0.05);观察组复发率显著低于对照组(P<0.05)。结论:甘草泻心汤联合美沙拉嗪治疗UC能显著改善患者临床症状及体征、提高患者生活质量。调节血清炎症细胞因子水平、参与免疫调节可能是其治疗UC和预防复发的主要机制。
Objective: To investigate the clinical efficacy of Gancao Xiexin Decoction combined with Mesalazine in the treatment of ulcerative colitis (UC) and its effect on serum inflammatory cytokines. Methods: 88 patients with UC (cold and heat miscellaneous type) were randomly divided into observation group and control group, 44 cases in each group. The control group was given mesalazine sustained release granules orally, 1.0 g / time, 4 times / day; the observation group was added with Gancaoxiexin Decoction on the basis of the control group. Two courses of treatment were 2 months, comparing the clinical efficacy and serum inflammation index changes. Results: The total effective rate of observation group, the total effective rate of TCM syndromes were significantly higher than that of the control group (P <0.05). After treatment, the scores of TCM syndromes, Baron score, serum TNF-α, IL- IL-17 and IL-23 in the observation group were significantly lower than those in the control group (P <0.05), IBDQ score and serum IL-10 were significantly higher in the observation group than in the control group (P <0.05) . Conclusion: Gancaixiexin Decoction combined with mesalazine in the treatment of UC can significantly improve the clinical symptoms and signs of patients and improve the quality of life of patients. Regulating serum levels of inflammatory cytokines involved in immune regulation may be its main mechanism for the treatment of UC and prevention of recurrence.