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目的:研究环氧合酶-2(COC-2)在胃癌、不典型增生及慢性萎缩性胃炎中的表达情况,探讨COX-2表达的预后意义。方法经手术病理证实的早、中期胃癌281例,进行预后随访调查。232例进行免疫组织化学染色。检则COX-2在胃癌及非癌组织中的表达情况,分析其与预后的关系。结果:早期胃癌的5年生存率为93.4％,中期胃癌的5年生存率为59.0％。COX-2在慢性萎缩性胃炎中的表达明显低于不典型增生者(P<0.01),在癌组织中的表达明显高于非癌组织(P<0.05～0.01);COX-2与胃癌淋巴结转移、血管浸润均密切相关(P<0.01);COX-2阳性表达者5年生存率明显低于阴性者(P<0.01)。结论:COX-2在胃癌组织呈过度表达状态,与胃癌的生长和浸润转移关系密切,可以作为反映胃癌生物学行为和判断预后的有效指标。
Objective: To investigate the expression of cyclooxygenase-2 (COC-2) in gastric cancer, atypical hyperplasia and chronic atrophic gastritis and to explore the prognostic significance of COX-2 expression. Methods 281 cases of early and middle stage gastric cancer confirmed by surgery and pathology were followed up for follow-up. 232 cases of immunohistochemical staining. Detection of COX-2 in gastric cancer and non-cancerous tissue expression, analysis of its relationship with the prognosis. Results: The 5-year survival rate of early gastric cancer was 93.4% and the 5-year survival rate of intermediate gastric cancer was 59.0%. The expression of COX-2 in chronic atrophic gastritis was significantly lower than that in atypical hyperplasia (P <0.01), and the expression of COX-2 in cancerous tissue was significantly higher than that in non-cancerous tissue (P <0.05-0.01) (P <0.01). The 5-year survival rate of COX-2 positive patients was significantly lower than that of negative patients (P <0.01). CONCLUSION: COX-2 is overexpressed in gastric cancer and closely related to the growth and invasion and metastasis of gastric cancer, which may be used as an effective indicator of biological behavior and prognosis of gastric cancer.