论文部分内容阅读
目的:研究酸味中药复方对糖尿病大鼠血清一氧化氮(nitric oxide,NO)、一氧化氮合酶(nitric oxide synthase,NOS),血浆内皮素-1(endothelin-1,ET-1)、心钠素(atrial natriuretic factor,ANF)含量的影响,探讨其防治2型糖尿病血管病变的机制。方法:采用硝酸还原酶法检测糖尿病大鼠血清NO含量,NOS活性,放免法测血清ET-1、ANF的含量。结果:酸味中药复方组大鼠血清NO含量、NOS活性高于模型组(P<0.05),血浆ET-1、ANF的含量低于模型组(P<0.05)。结论:酸味中药复方可能通过增加血清NO含量,提高NOS活性及降低血浆ET、ANF含量防治糖尿病血管病变的。
OBJECTIVE: To study the effects of sour traditional Chinese medicine compound on serum nitric oxide (NO), nitric oxide synthase (NOS), endothelin-1 (ET-1) (Atrial natriuretic factor, ANF) content, to explore the mechanism of prevention and treatment of type 2 diabetic vascular disease. Methods: Nitric acid reductase method was used to detect serum NO and NOS activity in diabetic rats. The levels of ET-1 and ANF in serum were detected by radioimmunoassay. Results: The content of NO and the activity of NOS in the sour TCM group were higher than those in the model group (P <0.05). The content of plasma ET-1 and ANF in the compound group was lower than that of the model group (P <0.05). Conclusion: Sour TCM can prevent and treat diabetic angiopathy by increasing serum NO content, increasing NOS activity and decreasing plasma ET, ANF content.