唾液酸存在于细胞膜的寡糖侧链末端。细胞间的粘着性和接触抑制、细胞在溶液中的稳定性、细胞的癌变、癌的转移及扩散,以及肿瘤的抗原性等都与细胞表面的唾液酸及其所电离出来的负电荷有着密切的关系。据报导,唾液酸是血清糖蛋白变化的一个敏感的指标,可应用于人癌瘤生长的动态观察。癌细胞表面的唾液酸含量高于正常相应的细胞,并且可以反映到血清中,使癌患者血清 Sialic acid is present at the end of the oligosaccharide side chain of the cell membrane. Adhesion and contact inhibition between cells, stability of cells in solution, canceration of cells, metastasis and spread of cancer, and antigenicity of tumors are closely related to the negative charge on the cell surface of sialic acid and its ionization. Relationship. It has been reported that sialic acid is a sensitive indicator of serum glycoprotein changes and can be applied to the dynamic observation of human cancer growth. The content of sialic acid on the surface of cancer cells is higher than that of normal cells and can be reflected in the serum to make cancer patients’ serum