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[目的]探讨纳洛酮对急性脑梗死患者血浆一氧化氮(NO)和内皮素(ET)的影响及临床疗效。[方法]将64例急性脑梗死病人随机分为纳洛酮治疗组(常规治疗+纳洛酮)和对照组(常规治疗),两组分别在治疗前和治疗后6、12、24、48h和72h抽取肘静脉血5ml,检测各组各时间点血浆的NO和ET含量,同时通过NDS评定治疗期内两组的治疗效果。[结果]纳洛酮治疗组治疗后6h血浆NO含量开始上升,ET含量下降,而对照组NO和ET含量变化不明显,在治疗期内NO和ET的含量比较两组差异有统计学意义(P﹤0.05),同时NDS评定纳洛酮治疗组好于对照组(P﹤0.05)且纳洛酮治疗组未见明显不良反应。[结论]纳洛酮可能通过纠正脑内NO和ET比例失衡来改善梗死区的缺氧症状达到治疗目的,用纳洛酮治疗急性脑梗死安全有效,值得临床推广。
[Objective] To investigate the effect of naloxone on plasma nitric oxide (NO) and endothelin (ET) in patients with acute cerebral infarction and its clinical efficacy. [Methods] 64 patients with acute cerebral infarction were randomly divided into naloxone treatment group (conventional treatment + naloxone) and control group (conventional treatment), two groups before and 6,12,24,48h And 72h elbow venous blood 5ml, detect the plasma NO and ET levels in each group at the same time, and through the NDS assessment of the treatment effect of the two groups during the treatment. [Results] The content of NO began to rise and the content of ET decreased at 6h after treatment in naloxone treatment group, while the content of NO and ET in control group did not change obviously. There was significant difference between the two groups in the content of NO and ET P <0.05). NDS was also better in the Naloxone treatment group than the control group (P <0.05) and no significant adverse reactions were observed in the Naloxone treatment group. [Conclusion] Naloxone may improve the hypoxic symptoms of infarct area by correcting imbalance of NO and ET in the brain, and it is safe and effective to treat acute cerebral infarction with naloxone. It is worthy of clinical promotion.