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植物生物技术的发展以及植物和寄生线虫之间相互作用机制研究的逐步深入，为利用基因工程方法防治线虫病害提供了许多新的策略。寄生于植物根部的栖居型线虫会诱导根部产生特异性取食结构，会在此完成发育、繁殖等生活史。同时被线虫感染的根部几天后取食位点细胞编码同线虫取食相关的酶或蛋白的基因被激活，而其它基因表达则被抑制甚至关闭。本文对有关抗线虫基因的克隆，利用基因工程手段获取抗线虫转基因植物以破坏线虫侵入、取食和繁殖等生活史中的几个阶段等方面的研究进展进行了综述。
The development of plant biotechnology and the research on the mechanism of interaction between plant and parasitic nematodes have provided many new strategies for using genetic engineering methods to control nematode diseases. Dwelling nematode parasitic on plant roots induces specific feeding structures at the root and completes the life history of development and reproduction. At the same time, nematode-infected roots of feeding sites several days after feeding site-specific genes or enzymes of nematode-feeding enzymes or proteins are activated, while other gene expression was inhibited or even closed. This review summarizes recent progress in the cloning of nematode resistance genes and the use of genetic engineering techniques to obtain transgenic nematode resistant plants in order to disrupt nematode invasion, feeding, and reproduction.