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本文对65例胆红素钙结石患者胆道(胆汁和胆囊粘膜)进行定性和定量细菌培养,测定患者胆汁的β-葡萄糖醛酸酶(β-G)活性,并观察比较主要厌氧菌(脆弱拟杆菌、产气荚膜梭菌)和需氧菌(大肠杆菌)各自产生的β-G 的有关生化特性。结果表明,胆道厌氧菌检出率高,与需氧菌相比,胆汁中细菌数多,产酶能力强,产酶量高,其β-G 更能分解结合胆红素且持续时间长。厌氧菌还能使较多的组织性β-G 释放和分解结合胆盐。此结果提示厌氧菌在 CBS 形成过程中较需氧菌具有更重要作用。
In this paper, 65 patients with bilirubin calculi in biliary tract (bile and gallbladder mucosa) qualitative and quantitative bacterial culture, determination of bile β-glucuronidase activity (β-G), and to observe the comparison of the main anaerobic bacteria Bacteroides, Clostridium perfringens) and aerobic bacteria (Escherichia coli). The results showed that the detection rate of bile anaerobic bacteria was high. Compared with aerobic bacteria, bile bacteria had more bacteria, strong enzyme producing ability and higher enzyme production, and its β-G was more able to decompose and bind with bilirubin for a long time . Anaerobic bacteria can also make more organized β-G release and decomposition combined with bile salts. The results suggest that anaerobic bacteria play a more important role in the formation of CBS than aerobic bacteria.