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乙型肝炎病毒(HBV)为非细胞毒性病毒,宿主在HBV感染后产生的免疫应答在HBV清除及乙型肝炎发病机制上发挥了重要的作用。乙型肝炎的转归与机体免疫状态密切相关,其中T淋巴细胞作为主要的效应细胞,与病毒清除和细胞损伤的发生直接相关。白细胞分化抗原(CD)是不同血细胞在正常分化、成熟、活化过程中出现或消失的细胞表面标志。与T细胞识别、黏附、活化有关的CD分子有CD2、CD3、CD4、CD8、CD28、CD58、CD80、CD86等,深入了解各种CD分子在HBV感染中的功能及变化,将为理解乙型肝炎慢性化机制及临床治疗提供新的思路及方向。
Hepatitis B virus (HBV) is a non-cytotoxic virus. The host’s immune response after HBV infection plays an important role in the pathogenesis of HBV clearance and hepatitis B. The prognosis of hepatitis B is closely related to the immune status of the body, of which T lymphocytes as the main effector cells, and virus clearance and cell damage is directly related to the occurrence. Leukocyte differentiation antigen (CD) is a cell surface marker that different blood cells appear or disappear during normal differentiation, maturation and activation. CD2, CD3, CD4, CD8, CD28, CD58, CD80, CD86 and other CD molecules related to T cell recognition, adhesion and activation have a deep understanding of the functions and changes of various CD molecules in HBV infection. Chronic hepatitis mechanism and clinical treatment provide new ideas and directions.