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目的:探析喹诺酮类药物在临床应用中的不良反应发生情况。方法:选择2014年2月-2015年12月期间我院收治的服用喹诺酮类药物250例患者为研究对象,回顾性分析其临床资料,总结不良反应发生情况。结果:本组的250例患者中,100例发生不良反应,发生率为40.0%,其中2例为血液系统,占2%,4例为泌尿系统,占4%,6例为心血管系统,占6%,7例为呼吸系统,占7%,15例为消化系统,占15%,20例为神经系统,占20%,46例为变态反应,占46%;不良反应发生时间:30例为静脉输液中,占30%,15例为用药后1d,占15%,29例为用药后2-3d,占29%,26例为用药后4-10d,占26%。结论:临床上运用喹诺酮类药物时,应该加强药学监测,合理选择药物,从而使不良反应发生率降低。
Objective: To investigate the adverse reactions of quinolones in clinical application. Methods: Two hundred and fifty patients taking quinolones in our hospital from February 2014 to December 2015 were selected as the research object. The clinical data were retrospectively analyzed and the incidence of adverse reactions was summarized. Results: Of the 250 patients in this study, 100 patients developed adverse reactions with a rate of 40.0%, of which 2 were hematological (2%), 4 were urinary (4%), 6 were cardiovascular, Accounting for 6%, 7 cases of the respiratory system, accounting for 7%, 15 cases of the digestive system, accounting for 15%, 20 cases of the nervous system, accounting for 20%, 46 cases of allergic reactions, accounting for 46%; adverse reaction time: 30 Cases of intravenous infusion, accounting for 30%, 15 cases of 1d after treatment, accounting for 15%, 29 cases of 2-3d after administration, accounting for 29%, 26 cases after treatment for 4-10d, accounting for 26%. Conclusion: When quinolones are used clinically, pharmacy monitoring should be strengthened and drugs should be chosen reasonably so as to reduce the incidence of adverse reactions.