新生儿出血症(hemorrhagic disease of the newborn,HDN)由于维生素K依赖性凝血因子Ⅱ、Ⅶ、Ⅸ、Ⅹ缺乏所引起的出血性疾病,故又称维生素K缺乏性出血症[1]。新生儿出血症临床表现多种多样,如注射部位出血不止、脐残端渗血、皮肤黏膜出血、消化道出血甚至颅内出血等,常并发于其他疾病而容易 Hemorrhagic disease of the newborn (HDN) is also known as vitamin K-deficient hemorrhagic disease due to a hemorrhagic disease caused by deficiency of vitamin K-dependent coagulation factors II, VII, IX and X [1]. The clinical manifestations of neonatal hemorrhagic disease varied, such as bleeding at the injection site more than the umbilical stump bleeding, mucocutaneous bleeding, gastrointestinal bleeding or intracranial hemorrhage, often complicated by other diseases and easy