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目的探讨丁苯酞软胶囊联合血栓通注射液对脑梗死急性期患者神经功能恢复的临床疗效及安全性。方法选择2012年1月—2014年7月收治的100例急性脑梗死患者作为研究对象,随机分为对照组和治疗组各50例。对照组给予常规治疗,试验组在对照组的基础上加用丁苯酞软胶囊联合血栓通注射液,疗程为30 d。观察两组患者治疗前及治疗后14、30 d国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)评分及日常生活活动Barthel指数得分情况。计量资料组间比较采用t检验,组内比较采用配对t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果试验组治疗后14、30 d NIHSS得分分别为(3.37±3.03)、(2.48±1.05)分,均低于治疗前的(6.00±3.30)分,差异均有统计学意义(均P<0.05)。治疗后14、30 d,试验组NIHSS得分均低于对照组的(5.65±4.00)、(3.00±1.43)分,差异均有统计学意义(均P<0.05)。试验组治疗后14、30 d Barthel指数分别为(78.56±20.16)、(85.21±15.28)分,均低于治疗前的(65.38±27.98)分,差异均有统计学意义(均P<0.05)。治疗后14、30 d,试验组Barthel指数均低于对照组的(70.05±20.75)、(78.52±16.37)分,差异均有统计学意义(均P<0.05)。试验组总有效率为94%,高于对照组的72%,差异有统计学意义(P<0.05)。结论丁苯酞软胶囊联合血栓通对脑梗死急性期患者神经功能恢复具有显著的促进作用,临床疗效安全可靠,值得进一步推广应用。
Objective To investigate the clinical efficacy and safety of Butylphthalide Soft Capsule combined with Xuesaitong Injection in the recovery of neurological function in patients with acute cerebral infarction. Methods A total of 100 patients with acute cerebral infarction who were admitted to our hospital from January 2012 to July 2014 were randomly divided into control group and treatment group. The control group was given routine treatment. The experimental group was given butylphthalide soft capsule combined with Xueshuantong injection on the basis of the control group for 30 days. The scores of National Institutes of Health Stroke Scale (NIHSS) scores and Barthel index of daily living activities before treatment and 14 and 30 days after treatment were observed in both groups. Measurement data were compared between groups using t test, the group was compared using paired t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The scores of NIHSS in the experimental group were (3.37 ± 3.03) and (2.48 ± 1.05) at 14 and 30 days after the treatment, respectively, which were lower than those before treatment (6.00 ± 3.30), the differences were statistically significant (P <0.05 ). At 14 and 30 days after treatment, the NIHSS scores in the experimental group were significantly lower than those in the control group (5.65 ± 4.00 and 3.00 ± 1.43, respectively, P <0.05). The Barthel index of the experimental group was (78.56 ± 20.16) and (85.21 ± 15.28) points at 14 and 30 days after treatment, respectively, which were lower than those before treatment (65.38 ± 27.98), the differences were statistically significant (all P <0.05) . At 14 and 30 days after treatment, Barthel index of the experimental group was significantly lower than that of the control group (70.05 ± 20.75) and (78.52 ± 16.37) points, respectively (all P <0.05). The total effective rate of the experimental group was 94%, which was higher than that of the control group (72%), the difference was statistically significant (P <0.05). Conclusion Butylphthalide soft capsule combined with Xueshuantong can significantly improve the neurological function in patients with acute cerebral infarction. The clinical efficacy is safe and reliable, which deserves further application.