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目的:应用鼻塞持续气道正压通气(NCPAP)及NCPAP联合盐酸氨溴索治疗新生儿呼吸窘迫综合征(NRDS),比较两种方法的疗效。方法:将52例给予NCPAP的患儿随机双盲分为两组,单用NCPAP组26例为对照组,NCPAP联用盐酸氨溴索组26例为治疗组,盐酸氨溴索剂量为30 mg/(kg.d)加入10%葡萄糖注射液5 mL稀释后用微量输液泵静脉滴入,时间>5 min,每6 h一次,连用3 d。观察治疗前后两组患儿的呼吸指标、X线胸片、用氧时间、住院时间及并发症情况。结果:治疗组应用盐酸氨溴索24 h后,呼吸指标、X线胸片较对照组明显改善,住院天数(t=3.45,P<0.05)及用氧时间(t=4.35,P<0.01)较对照组明显减少,两组比较差异有统计学意义。结论:NCPAP联合盐酸氨溴索治疗NRDS能快速有效地改善肺功能,减少机械通气使用率,缩短用氧时间和住院天数。
OBJECTIVE: To treat nasal respiratory distress syndrome (NRDS) with nasal continuous positive airway pressure (NCPAP) and NCPAP combined with ambroxol hydrochloride. The curative effects of the two methods were compared. Methods: Fifty-two children with NCPAP were randomly divided into two groups. NCPAP group (26 cases) was used as control group, NCPAP group (26 cases) was treated with ambroxol hydrochloride group, and ambroxol hydrochloride dose was 30 mg /(kg.d) 10% glucose injection by adding 5 mL of diluted infusion intravenous infusion, time> 5 min, once every 6 h, once every 3 d. Before and after treatment in both groups observed respiratory index, X-ray, oxygen time, hospital stay and complications. Results: After treatment with Ambroxol Hydrochloride for 24 hours, the respiratory index and X-ray were significantly improved in the treatment group (P <0.05) Compared with the control group was significantly reduced, the difference between the two groups was statistically significant. Conclusion: NCPAP combined with ambroxol hydrochloride in the treatment of NRDS can improve pulmonary function quickly and effectively, reduce the rate of mechanical ventilation, shorten the duration of oxygen use and length of stay.